Giotto, The Slaughter of the Innocents

1303-1305
Fresco
Scrovegni Chapel, Padua

This image is based on Matthew 2:16-18. Herod gives the order from above as the men murder the boys. They use their fists rather than the swords and pikes ordinarily seen in images of this type.

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Photographed at the chapel by Richard Stracke, shared under Attribution-NonCommercial-ShareAlike license.